My friends at Karelia have released Sandvox 2, which is a nice Mac app which will help you create websites- "Easy, elegant website creation". Sandvox has a bunch of templates to choose from, and you can publish to multiple types of servers as well (MobileMe, SFTP, WebDAV).

Dan has also given me a coupon code to hand out to everyone- you can use "FLYINGMEAT" until May 20th for 20% off. Check it out.